Health, social, and economic (HSE) effects of development and resource projects are interconnected topics formally addressed in the field of Impact Assessment (IA). These topics directly relate to the human environment, which is sensitive and ever-changing. Adverse HSE effects are some of the most unwanted, whereby mitigation efforts focus on safeguarding individuals, families, and communities from harm. Efforts are also encouraged by different proponents to support and enhance positive HSE effects. While there is a broad consensus that development projects should be built to bring benefit to societies, experience across sectors has demonstrated that there are always sensitive times and challenging issues within the social context of a project that emerge unexpectedly. Therefore, mitigation planning, design, and implementation for HSE effects requires the merging of disciplines, concepts, data sets, and ideas. A different approach is required as compared to steps and processes taken by environmental practitioners and colleagues. The Asia Pacific Foundation for Climate and Health (ACH) was commissioned by the Impact Assessment Agency of Canada (IAAC) to conduct research focused on mitigation and enhancement good practices, recommendations, and options for common HSE effects. This research was driven by an increased focus on HSE effects under the updated Impact Assessment Act (IAA) along with a desire by IAAC to support improved performance in this area. This research report is tightly scoped and targets practitioners who provide impact assessment services and proponents who have projects in Canada, or Canadian funded projects in other countries. The overarching objective of this research is to provide a synthesis of essential resources drawing from international standards as it relates to mitigation and enhancement measures for HSE effects. Findings from research do not explicitly tell practitioners or proponents how to mitigate specific HSE effects as it is ACH’s position that each project and community hold a distinct and unique interaction. A core message that flows throughout this report is that effective HSE mitigations need to be specific and adapted to the context in which a project is situated and to the people who are affected. The goal of this work is to address recommendations made by IAAC’s Technical Advisory Committee (TAC) on HSE effects to enhance practitioner resources in this area. This research report is organized into four sections aside from the introduction. Section 2 describes research activities conducted by the ACH team. Section 3 provides a brief summary of the IAA in Canada; a high-level overview of the Impact Assessment process for designated projects under IAA; and existing guidance from IAAC for assessing HSE effects and designing mitigation/enhancement measures. Section 4 describes the findings from the research activities and provides a synthesis of mitigation/enhancement measures for different sectors for common HSE effects. Section 5, the final section of the report, provides recommendations based on research report findings. In summary, this research report provides a synthesis of leading standards and resources that have been found to directly guide and inform the development and implementation of successful HSE mitigation and enhancement measures for projects in Canada and around the globe.