Psycho-social impact assessment (PSIA) explores real and potential impacts on “lifescape,” “lifestyle,”and “lifestrain.” PSIA can inform strategies to mitigate negative effects, such as stress loads, andenhance the ability of individuals and communities to cope or flourish. Like environmental, social and health impact assessment, PSIA ideally helps to achieve a just, equitable, positive outcome for affected communities. Participatory processes can enable those who are likely to be more vulnerable or less resilient to be heard. SIA involves an interplay of professions, including social and environmental psychology, community psychology, sociology, cultural anthropology, and community health. Combining these disciplinary perspectives and views of multiple stakeholder groups creates challenges. Add to that a need to address cumulative psycho-social impacts with multiple causes.